Dihydroindolone Derivatives Information

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Type of Drug:

Typical (conventional) antipsychotic.

How the Drug Works:

The exact mechanism of action, like other drugs used to treat psychotic disorders, is not known.

Uses:

For the management of manifestation of psychotic disorders (mental illnesses).

Precautions:

Tardive dyskinesia: Involuntary and uncontrollable movements may develop in patients treated with antipsychotic drugs. Occurrence is highest in the elderly, especially women. However, it is impossible to predict which patients are likely to develop the syndrome. The risk of developing these involuntary movements and the likelihood they will become permanent are increased with long-term use and with high doses. However, it is possible to develop these symptoms batter shortterm treatment at low doses. The syndrome is characterized by rhythmical, involuntary movements of tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements), sometimes accompanied by involuntary movements of the arms and legs. Fine worm-like movement of the tongue may be an early sign of the syndrome. If the medication is stopped at this time, the syndrome may not develop further. There is no known treatment for established cases of tardive dyskinexia, although the syndrome may stop, partially or completely, if the drug is withdrawn. Antipsychotic treatment, however, may suppress or partially suppress the signs and symptoms of the syndrome and thereby may possibly mask the underlying disease process. The effect that symptomatic suppression has upon the long-term course of the syndrome is unknown.

Neuroleptic Malignant Syndrome (NMS): Is a potentially fatal syndrome lassociate with antipsychotic drugs. Symptoms nclude fever, muscle rigity,altered mental abilities, irregular pulse and blood pressure,increased heart rate ,sweating ,and irregular heart rhythm.

Pregnancy: There are no adequate and well-controlled studies in pregnant women. Use only if clearly needed and the potential benefits outweigh the possible hazards to the fetus.

Breastfeeding: It is not known if molindone appears in breast milk. Consult your doctor before you begin breastfeeding.

Children: Safety and effectiveness in children younger than 12 years of age have not been established; use is not recommended.

Sulfites: Molindone concentrate contains sodium metabisulfite, a sulfite that may cause allergic-type reactions, including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.

Drug Interactions:

Tell your doctor or pharmacist if you are taking or are planning to take any over-the-counter or prescription medications or dietary supplements while taking this drug. Doses or one or both drugs may need to be modified or a different drug may need to be prescribed. The following drugs and drug classes may interact with this drug:

CNS depressants (eg, antianxiety agents, narcotics, sedatives/hypnotics)

Phenytoin (eg, Dilantin)

Tetracyclines (eg, doxycycline)

Side Effects:

Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. Possible side effects include:

Digestive Tract: Constipation; dry mouth; increased salivation; nausea.

Nervous System: Drowsiness; inability to sit still; euphoria (exaggerated sense of well being); depression; tremor; twitching, abnormal movements; rigidity; immobility; abnormal movement of tongue, face, mouth, or jaw; involuntary arm or leg movement.

Urinary and Reproductive Tract: Urinary retention; absence of menstrual bleeding; heavy menstrual bleeding.

Other: Rash; weight changes; increased libido; blurred vision, persistent penile erection; impotence; fever; perspiration; rapid heart beat.

Guidelines for Use:

Dosage is individualized. Take exactly as prescribed.

Do not stop taking or change the dose, unless instructed by your doctor.

A combination of factors, (eg, people older than 65 years of age, females) may require dose adjustment.

May be taken with or without food.

If a dose is missed, take it as soon as possible. If several hours have passed or it is nearing time for the next dose, do not double the dose to catch up, unless instructed by your doctor. If more than one dose is missed or if it is necessary to establish a new dosage schedule, contact your doctor or pharmacist.

Avoid alcohol and other mental depressants (eg, narcotics, tranquilizers, antihistamines) while you are taking this medicine.

May cause drowsiness. Use caution while driving or performing other tasks requiring alertness, coordination, or physical dexterity.

Contact your doctor immediately if you experience fever, sweating, muscle rigidity, involuntary movements (of the face, tongue, arms, or legs), menstrual irregularities, rash, or abnormal heart rate or rhythm.

Inform your doctor if you are pregnant, become pregnant, are planning to become pregnant, or are breastfeeding.

Store at controlled room temperature (59 to 86F) away from light and moisture.

Article Source: http://depositarticles.com/

Get the full detail about the drugs their uses, benefits, side effects and precautions. Know about the various type of drugs such as blood modifiers , cardiovasculars and many more. To get this all in detail you can visit www.drug-facts.net/.

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